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The BTB domain binds Cul3, contains the Cysteine151 residue (C151), which is one of the important cysteine residues in stress sensing, and mediates KEAP1 homodimerization [123,124,125]

Suplemen glutathione juga kerap digunakan sebagai terapi tambahan pada beberapa kondisi medis, seperti psoriasis, diabetes, perlemakan hati, gangguan sirkulasi darah, penyakit autoimun, dan penyakit Parkinson